A great way of gathering some preliminary
data is to use the GEO DataSet Browser on NCBI. NCBI has many useful resources
and this database is one. Examples of its use include look at gene expression
changes in:
* tissues stimulated with
steroids, drugs, and other compounds;
* control vs diseased tissues;
* the effect of age;
* etc
Here is a link to the GEO DataSet Browser:
For those of you not familiar with it, just
type in your search term in the search box e.g. “alzheimers disease stages”.
Select a GDS dataset. Scroll down to the bottom and you should see 3 tabs
“Expression Profiles”, “Data Analysis Tools” and “Sample Subsets”. The
“Expression Profiles” tab will take you to the profiles of all the genes
screened. When you click on the “Data
Analysis Tools” tab a new section will appear below. Type in the name of your
GOI in the search box and you will be able to search for gene expression
changes in your GOI. The “Sample Subsets” tab provides information about the
samples used.
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